Helichrysum (Helichrysum italicum) has excellent anti-inflammatory properties and here are a couple of studies that have been done exploring this. 

Study 1 

The Journal of Alternative and Complementary Medicine
Vol. 19, No. 1
Published Online:14 Jan 2013 https://doi.org/10.1089/acm.2012.0089

Effect of Inhaled Essential Oils on Mental Exhaustion and Moderate Burnout: A Small Pilot Study

Elizabeth Varney and Jane Buckle

Abstract

Objectives: The objective of this pilot study was to determine the effectiveness of a mixture of essential oils (peppermint, basil, and helichrysum) on mental exhaustion, or moderate burnout (ME/MB) using a personal inhaler.

Design: This was a randomized, controlled, double-blind pilot study. Data were collected 3 times a day for 3 weeks (Monday–Friday). The first week was baseline for both groups, the second week was intervention (aromatherapy or placebo), and the third week was washout.

Settings/location: Participants used a personal inhaler at home or at work.

Subjects: The subjects comprised a convenience sample of 13 women and 1 man who each had self-assessed ME/MB.

Interventions: Participants were randomized to receive a personal inhaler containing either a mixture of essential oils or rose water (as used in Indian cooking).

Outcome measures: The outcome measures were a 0–10 scale with 10=worst feeling of burnout, 0=no feeling of burnout. There was a qualitative questionnaire rating aroma and a questionnaire listing perceived stressors.

Results: While both groups had a reduction in perception of ME/MB, the aromatherapy group had a much greater reduction.

Conclusions: The results suggest that inhaling essential oils may reduce the perceived level of mental fatigue/burnout. Further research is warranted.

Study 2

Journal of Pharmacy and Pharmacology Royal Pharmaceutical Society
Volume 54, Issue 3 , March 2002, Pages 365-371
First published: 18 February 2010 https://doi.org/10.1211/0022357021778600

Anti‐inflammatory and antioxidant properties of Helichrysum italicum

Araceli Sala, María del Carmen Recio,  Rosa María Giner,  Salvador Máñez , Horacio Tournier,  Guillermo Schinella,  José‐Luis Ríos

Abstract

The anti‐inflammatory and antioxidant activities of the aerial part of Helichrysum italicum extracts have been established in various in‐vivo and in‐vitro experimental models. The results obtained on the acute oedemas induced by 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) and ethyl phenylpropiolate in the mouse ear, by serotonin and phospholipase A2 (PLA2) in the mouse paw, on chronic inflammation induced by repeated application of TPA in the mouse ear and on the delayed‐type hypersensitivity induced by sheep red blood cells suggest that said anti‐inflammatory activity is due to the effects of compounds expressed via a corticoid‐like mechanism. In addition, the antioxidant activity of the extracts seems to be implicated in this anti‐inflammatory activity, as the former inhibits enzymatic and non‐enzymatic lipid peroxidation and has free‐radical scavenger properties. We conclude that the anti‐inflammatory activity of Helichrysum italicum can be explained by multiple effects, including inflammatory enzyme inhibition, free‐radical scavenging activity and corticoid‐like effects.